Neuroimaging of animal models of brain disease
Identifieur interne : 000A32 ( Main/Exploration ); précédent : 000A31; suivant : 000A33Neuroimaging of animal models of brain disease
Auteurs : Mark F. Lythgoe [Royaume-Uni] ; Nicola R. Sibson [Royaume-Uni] ; Neil G. Harris [Royaume-Uni]Source :
- British Medical Bulletin [ 0007-1420 ] ; 2003-03.
Abstract
The main aim of this review is to describe some of the many animal models that have proved to be valuable from a neuroimaging perspective. This paper complements other articles in this volume, with a focus on animal models of the pathology of human brain disorders for investigations with modern non-invasive neuroimaging techniques. The use of animal model systems forms a fundamental part of neuroscience research efforts to improve the prevention, diagnosis, understanding and treatment of neurological conditions. Without such models it would be impossible to investigate such topics as the underlying mechanisms of neuronal cell damage and death, or to screen compounds for possible anticonvulsant properties. The adequacy of any one particular model depends on the suitability of information gained during experimental conditions. It is important, therefore, to understand the various types of animal model available and choose an appropriate model for the research question.
Url:
DOI: 10.1093/bmb/65.1.235
Affiliations:
- Royaume-Uni
- Angleterre, Angleterre de l'Est, Grand Londres, Oxfordshire
- Cambridge, Londres, Oxford
- University College de Londres, Université d'Oxford, Université de Cambridge
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<front><div type="abstract" xml:lang="en">The main aim of this review is to describe some of the many animal models that have proved to be valuable from a neuroimaging perspective. This paper complements other articles in this volume, with a focus on animal models of the pathology of human brain disorders for investigations with modern non-invasive neuroimaging techniques. The use of animal model systems forms a fundamental part of neuroscience research efforts to improve the prevention, diagnosis, understanding and treatment of neurological conditions. Without such models it would be impossible to investigate such topics as the underlying mechanisms of neuronal cell damage and death, or to screen compounds for possible anticonvulsant properties. The adequacy of any one particular model depends on the suitability of information gained during experimental conditions. It is important, therefore, to understand the various types of animal model available and choose an appropriate model for the research question.</div>
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